A novel cis-acting element required for lipopolysaccharide-induced transcription of the murine interleukin-1 beta gene

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A novel cis-acting element required for lipopolysaccharide-induced transcription of the murine interleukin-1 beta gene.

Regulatory elements important for transcription of the murine interleukin-1 beta (IL-1 beta) gene lie within a DNase I-hypersensitive region located > 2,000 bp upstream from the transcription start site. We have identified within this region a novel positive regulatory element that is required for activation of an IL-1 beta promoter-chloramphenicol acetyltransferase (CAT) fusion gene in the mur...

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ژورنال

عنوان ژورنال: Molecular and Cellular Biology

سال: 1995

ISSN: 0270-7306,1098-5549

DOI: 10.1128/mcb.15.1.112